A., Korotkova, T. A., Toroptsova, N. V., Smirnov, A. V., Demin, N. V., Rodionova, S. S., Buklemeshev, IuV, and Shumskii, A. Two years ago I was put on vacation from the reclast and havent received any further infusions. Any feedback to help me through this maze will be highly appreciated. Strontium ranelate is associated with other harmful effects, including serious skin reactions, disturbances in thinking, seizures, liver inflammation, and reduced numbers of red blood cells. [Efficacy and safety of bivalos therapy for postmenopausal osteoporosis. To measure the effectiveness of it, researchers measured bone mineral density in the neck, spine and hip as well as some biochemical bone markers. Disease-modifying effect of strontium ranelate in a subset of patients from the Phase III knee osteoarthritis study SEKOIA using quantitative MRI: reduction in bone marrow lesions protects against cartilage loss. Its been interesting what research has shown to date aboutits use for osteoporosis. View abstract. D'Haese PC, Couttenye MM, Lamberts LV, et al. 2015 Feb;74(2):422-9. doi: 10.1136/annrheumdis-2013-203989. Krachler, M., Domej, W., and Irgolic, K. J. 1990;34(3):545-560. View abstract. Strontium is a trace mineral that may aid bone health by reducing bone loss and encouraging bone development. I was told by the endocrinologist who I went to for osteoporosis that AlgaeCal is no better than taking calcium and vitamin D. I am reading the book "Strong Women, Strong Bones" and I highly recommend it. Adami, S. Protelos: nonvertebral and hip antifracture efficacy in postmenopausal osteoporosis. Reginster, J. Y., Lecart, M. P., Deroisy, R., and Lousberg, C. Strontium ranelate: a new paradigm in the treatment of osteoporosis. (3). Kanapka, J. (24, 25). Medical studies done on the ingredients have shown conclusively that this product is effective. 5 Possible (and Controversial) Health Benefits, The Foods, Supplements & Oils to Increase Bone Healing, Daniel Fast: Benefits for Your Spiritual, Emotional and Physical Health, 15 Fermented Foods for a Healthy Gut and Overall Health, 9 Proven Black Seed Oil Benefits that Boost Your Health, L-Glutamine Benefits Leaky Gut & Metabolism, Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, Apple Cider Vinegar Benefits for Weight Loss, Skin Health, Cholesterol & More. are clickable links to these studies. 2006;3:CD005326. Bolland, M. J., Grey, A. 5-10-2001;344(19):1434-1441. Bone 2009;45(3):460-465. Information from this source is evidence-based and objective, and without commercial influence. Am on third brand of Strontium Citrate and doing better than on the first two. Please note the date of the last review on all articles. 2005;7(3):R625-R633. View abstract. Skoryna SC. A number of studies have shown that it can strengthen bone and reduce the risk of fractures, even among women 74 years of age or older when risks are highest. Reichenbach, S., Blank, S., Rutjes, A. W., Shang, A., King, E. A., Dieppe, P. A., Juni, P., and Trelle, S. Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. View abstract. Strontium Ranelate returns to the UK as an osteoporosis drug treatment. 2019, As a service to our readers, American Bone Health provides access to our library of archived content. View abstract. What else is it good for? Because strontium ranelate is a weak anti-resorptive agent and there are more effective osteoporosis agents in the United States and most countries, we do not use strontium ranelate in postmenopausal women with osteoporosis. Available at: www.atsdr.cdc.gov/toxprofiles/tp159.pdf. J.Bone Miner.Res. Clin Sci 1968;34:351-63. 2013 Feb;72(2):179-86. doi: 10.1136/annrheumdis-2012-202231. View abstract. View abstract. Zhai, H., Hannon, W., Hahn, G. S., Harper, R. A., Pelosi, A., and Maibach, H. I. Strontium nitrate decreased histamine-induced itch magnitude and duration in man. Note that the numbers in parentheses (1, 2, etc.) Dermatol.Surg. View abstract. Most people who take strontium citrate report their fractures STOP. For two years, 174 of the men received 2 grams of strontium ranelate per day while 87 men received a placebo. [2] Royal Osteoporosis Society. Strontium absorption also has effects on the absorption ofcalcium, magnesium and phosphate ions. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician, https://www.ema.europa.eu/en/news/prac-recommends-suspending-use-protelososseor, https://theros.org.uk/latest-news/2019-01-14-strontium-ranelate-returns-to-the-uk-as-an-osteoporosis-drug-treatment. They. View abstract. [4] Simpson, Lani. Also, the FDA doesnt regulate supplements in the same way as prescription drugs, so it's not possible to know if if they are safe or work well or even how much of the main ingredient they contain. 1992;19(10):737-740. J Can Dent Assoc 2003;69:221-6. Arthritis Rheum 2007;56(7):2105-2110. Br.J.Clin.Pharmacol. Kidney Int 2003;64:534-43. . Gillam, D. G., Newman, H. N., and Bulman, J. S. The effect of strontium chloride hexahydrate dentifrices on plaque accumulation and gingival inflammation. It's not known if strontium. It is prescribed only for those who would otherwise have no other suitable treatment to reduce their risk of broken bones.[2]. View abstract. AlgaeCal Plus is a plant-based calcium supplement that contains all 13 bone-supporting minerals and is clinically supported to increase bone density. Because strontium and calcium have very similar molecular structures, the body treats them much the same. O'Donnell, S., Cranney, A., Wells, G. A., Adachi, J. D., and Reginster, J. Y. Strontium ranelate for preventing and treating postmenopausal osteoporosis. McAlindon TE, LaValley MP, Gulin JP, Felson DT. A generic, non-branded version of strontium ranelate, from Aristo Pharma Ltd., is still available in the U.K.[2] with a number of special warnings and precautions for its use. After you stop taking any of these bone-building medications, you generally will need to take another osteoporosis drug to maintain the new bone growth. View abstract. (18), Sr is said to be the 15th most abundant element on Earth and its common to find it in nature. Doggrell, S. A. Strontium and calcium metabolism. Today we will talk to our Cleveland Clinic experts regarding steps you can take to prevent this disease and treatments that may be needed. 9-1-2005;30(17 Suppl):S84-S91. Here with us today, we have two experts. Strontium-89 chloride in the treatment of bone metastases from breast cancer. View abstract. View abstract. Strontium controls the activity of OPG and RANKL; these are essential molecules that regulate the rates of bone resorption. Small doses of strontium citrate are generally safe and effective, but some sensible precautions apply. Available at: https://www.fda.gov/cder/ogd/approvals/1stgen0103.htm. I feel that I need something that is shown to rebuild bone (15 lumbar and thoracic vertebral compression fractures). The product can increase bone density, and it can also slow down bone loss. 1992;71 Spec No:841-845. 23(1):305-315. doi: 10.1007/s00198-011-1758-z. 2011;(7):CD003347. Scand J Rheumatol 2001;30(4):242-247. Effectiveness of desensitizing agents. View abstract. 2006;45(3):179-185. Human biokinetics of strontium--part II: Final data evaluation of intestinal absorption and urinary excretion of strontium in human subjects after stable tracer administration. Instant breakfast drink, various flavors and brands, powder prepared with water, 8 ounces 105-250 mg per serving. Strontium 89 in the treatment of pain due to diffuse osseous metastases: a university hospital experience. View abstract. 2013 Feb;98(2):592-601. doi: 10.1210/jc.2012-3048. Dijkgraaf-Ten Bolscher M, Netelenbos JC, Barto R, van der Vijgh WJ. View abstract. I will be contacting my urologist who I just began working with to let her know about Strontium. Hernandez, F., Mohammed, C., Shannon, I., Volpe, A., and King, W. Clinical study evaluating the desensitizing effect and duration of two commercially available dentifrices. J BoneMiner Res 2002;17 [Suppl 1](S35). View abstract. Les Laboratoires Servier, 2006. Various tests for tooth sensitivity by the researchers revealed that compared to the placebo, the toothpaste containing Sr decreased dentinal hypersensitivity to a significantly greater degree. Positive results were seen within two weeks and continued for the 12 week length of the study. 1990;12(4):28-33. Effect of risedronate on the risk of hip fracture in elderly women. Is Lamb Healthy? 11-30-1995;333(22):1437-1443. View abstract. Mayo docs say it will stay in my system for up to three years. Overview. View abstract. Overall, the review concludes: For patients with castration-resistant prostate cancer suffering from malignant bone pain, treatment with a bone-seeking radiopharmaceutical is a relevant therapeutic option often resulting in significant pain reduction. Liu, J. M., Wai-Chee, Kung A., Pheng, C. S., Zhu, H. M., Zhang, Z. L., Wu, Y. Y., Xu, L., Meng, X. W., Huang, M. L., Chung, L. P., Hussain, N. H., Sufian, S. S., and Chen, J. L. Efficacy and safety of 2 g/day of strontium ranelate in Asian women with postmenopausal osteoporosis. Dr. Lanis No-Nonsense Bone Health Guide. Accessed May 1, 2018. Some quinolone antibiotics include ciprofloxacin (Cipro), gemifloxacin (Factive), levofloxacin, moxifloxacin (Avelox), and others. Uchida, A., Wakano, Y., Fukuyama, O., Miki, T., Iwayama, Y., and Okada, H. Controlled clinical evaluation of a 10% strontium chloride dentifrice in treatment of dentin hypersensitivity following periodontal surgery. I wont name names, but some of the most well-known toothpastes for sensitive teeth include strontium in their formulas. 1996;67(8):737-742. Some tetracycline antibiotics include demeclocycline (Declomycin), minocycline (Minocin), and tetracycline. Malaise, O., Bruyere, O., and Reginster, J. Y. Strontium ranelate normalizes bone mineral density in osteopenic patients. Do not be misled by marketing materials that compare them to strontium ranelate. View abstract. N Engl J Med 2004;350:459-68.. View abstract. Spets-Happonen, S., Seppa, L., Korhonen, A., and Alakuijala, P. Accumulation of strontium and fluoride in approximal dental plaque and changes in plaque microflora after rinsing with chlorhexidine-fluoride-strontium solution. What does this alkaline earth metal look like in nature? A new desensitizing dentifrice: preliminary report. Towheed TE, Maxwell L, Anastassiades TP, et al. The compound Strontium Citrate has CAS number 40182-75- and molecular formula C6H5O7Sr-. Because strontium atoms are heavier than calcium atoms, swapping some of the calcium atoms with strontium atoms will make the bone mineral density appear to increase. A., Thompson, D. E., Nevitt, M. C., Bauer, D. C., Genant, H. K., Haskell, W. L., Marcus, R., Ott, S. M., Torner, J. C., Quandt, S. A., Reiss, T. F., and Ensrud, K. E. Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. J.Periodontol. O'Donnell S, Cranney A, Wells GA, et al. Also, the FDA doesnt regulate supplements in the same way as prescription drugs, so it's not possible to know if if they are safe or work well or even how much of the main ingredient they contain. 1998-2023 Mayo Foundation for Medical Education and Research. Cochrane.Database.Syst.Rev. Busse, B., Jobke, B., Hahn, M., Priemel, M., Niecke, M., Seitz, S., Zustin, J., Semler, J., and Amling, M. Effects of strontium ranelate administration on bisphosphonate-altered hydroxyapatite: Matrix incorporation of strontium is accompanied by changes in mineralization and microstructure. Minkoff S, Axelrod S. Efficacy of strontium chloride in dental hypersensitivity. Taking strontium with tetracyclines can decrease their effects. 2006;(1):CD005117. Strontium Boost is supposed to have no side effects at all. View abstract. View abstract. Radiother Oncol 1994;31:33-40. Can Med Assoc J 1981;125:703-12.. View abstract. (19), If youre a fan of red fireworks, you can thank strontium (specificallygaseous strontium monochloride) for that brilliant color you see every 4th of July. Cummings, S. R., Black, D. M., Thompson, D. E., Applegate, W. B., Barrett-Connor, E., Musliner, T. A., Palermo, L., Prineas, R., Rubin, S. M., Scott, J. C., Vogt, T., Wallace, R., Yates, A. J., and LaCroix, A. View abstract. The drug name for this radioactive form is Metastron. Protelos European Public Assessment Report, Scientific Discussion. View abstract. Omdahl JL, DeLuca HF. 5 Reasons to Add Lamb Meat to Your Diet. No difference in intestinal strontium absorption after an oral or an intravenous 1,25(OH)2D3 bolus in normal subjects. 1998;4(2):114-119. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. Is reclast a safe treatment for osteoporosis I have not done anything so far except strontium citrate? Strontium is a trace mineral that may help keep bones strong by preventing bone loss and promoting bone growth. 1986;12(9):447-454. FDA. Founded in 1999, ConsumerLab.com is a leading provider of consumer information and independent evaluations of products that affect health and nutrition. View abstract. Reduce bone loss and build stronger muscles. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. 2007;19(4):330-333. View abstract. It is an alkaline earth metalmost similar to barium and calcium. It was recommended to my sister by her doctor. It seems to play a role in how your body makes new bone while it slows the breakdown of old bone. Some people say this supplement improves bone health, but its important to think about its benefits and risks before you decide to take it. Fracture Intervention Trial Research Group. View abstract. and I don't hear much about it. ", UC Davis School of Medicine: "Strontium Citrate for Osteoporosis Prevention Evaluation (SCOPE). . Strontium is an element that has been shown to improve bone healing. Meanwhile, strontium citrate features a 31% elemental strontium and only 69% citrate. The effect of prior bisphosphonate therapy on the subsequent therapeutic effects of strontium ranelate over 2 years. Faith123 may be able to answer a question or two of yours about the reclast infusion treatment and her experience with it. 2000;83(5):657-660. View abstract. Strontium ranelate may cause unwanted side effects such as stomach pain, diarrhea and headache. Strontium Ranelate returns to the UK as an osteoporosis drug treatment. 2019https://theros.org.uk/latest-news/2019-01-14-strontium-ranelate-returns-to-the-uk-as-an-osteoporosis-drug-treatment. (14). A meta-analysis of randomized controlled trials. Robinson RG, Preston DF, Schiefelbein M, Baxter KG. Next year will be my third year off the reclast so it will be interesting to see what docs will then suggest. Ashayeri E, Omogbehin A, Sridhar R, Shankar RA. (7,8), There have been more studies that show the positive effects of strontium ranelate on osteoporosis and bone fractures. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis--a 2-year randomized placebo controlled trial. Rev Rhum Engl Ed 1997;64(12):825-834. First, fluoride makes your tooth enamel stronger and less likely to suffer acid damage . Boron is an element. With a few simple measures, the application of Sr-89 causes no problems. Appelboom, T., Schuermans, J., Verbruggen, G., Henrotin, Y., and Reginster, J. Y. The most common form of strontium in nutritional supplements is strontium citrate. A coordinator will follow up to see if Mayo Clinic is right for you. Loutit, J. F. Diurnal variation in urinary excretion of calcium and strontium. This family of meds give your natural bone production a chance to play catch-up by slowing or stopping resorption, when bones break down and release minerals such as calcium into your blood. J.Dent.Res. JAMA 2000;283:1469-75. CMAJ. Papoiu AD, Valdes-Rodriguez R, Nattkemper LA, Chan YH, Hahn GS, Yosipovitch G. A novel topical formulation containing strontium chloride significantly reduces the intensity and duration of cowhage-induced itch. Results 12 weeks following cessation of 8 weeks' supervised use. You can buy different forms of it, such as strontium citrate, in supplements at supermarkets and health food stores. Medi-Physics, Inc., Amersham Healthcare, Arlington Heights, IL, 1998. https://www.cancerpaintherapy.com/METATECHPAGE.htm. A., Mohr, D. N., Petterson, T. M., O'Fallon, W. M., and Melton, L. J., III. A. Hyaluronic acid injections relieve knee pain. View abstract. There were, however, significant increases in both heart attacks and blood clots (including pulmonary embolism) in patients taking strontium ranelate compared to those who were not. Toxicological profile for strontium. View abstract. Stable strontiums atomic symbol is Sr, its atomic number is 38 and its atomic weight is 87.62. Marie PJ, Ammann P, Boivin G, Rey C. Mechanisms of action and therapeutic potential of strontium in bone. If youre not into chemistry, then those scientific facts probably dont mean that much to you. Calcium is important for bone health throughout your life. Calcium citrate has an acidic base, so it doesn't require hydrochloric acid for absorption. A double blind, prospective, placebo-controlled study. View abstract. Middleton ET, Steel SA, Aye M, Doherty SM. Lets take a look at the possible health benefits of strontium. 1996;41(6):543-549. A prescription form of strontiumstrontium ranelate (the ranelate salt), known as Protelos/Osseor was authorized in the European Union to treat severe osteoporosis in women who have been through the menopause and men who are at high risk of broken bones or fracture in the spine and the hip. Drug Ther Bull. (10), Radioactive strontium-89 is given intravenously for advanced bone cancer or cancer that has spread to the bones such as metastatic prostrate cancer. 1992;63(1):7-12. How can Sr be used? J.Clin.Periodontol. J.Dent.Res. Strontium ranelate for preventing and treating postmenopausal osteoporosis. Sr should be used with caution for those with kidney disease and if you have advanced kidney disease, then strontium ranelate is not recommended at all. While it may seem intimidating at first, counting macros is a common Erythritol is now one of the most popular natural zero-calorie sweeteners available. Is it even safe? Ter.Arkh. Pelletier JP, Roubille C, Raynauld JP, et al. View abstract. It may even cause constipation or digestive discomfort. View abstract. Blake, G. M., Zivanovic, M. A., McEwan, A. J., and Ackery, D. M. Sr-89 therapy: strontium kinetics in disseminated carcinoma of the prostate. Arthritis Rheum 1998;41:81-91. 2006;(2):CD005321. Dent.Clin.North Am. Prostate cancer. 2002;13(12):925-931. View abstract. Basically, it is like you are consuming rocks. A special form of strontium called strontium ranelate can increase bone formation and prevent bone loss when used in postmenopausal women with osteoporosis. JAMA 10-13-1999;282(14):1344-1352. April 2004. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. Adouble-blind, parallel, comparative study study published back in 1987 in the Journal of Periodontology looked at the effects of a toothpaste containing10 percent strontium chloride hexahydrateon 61 subjects with hypersensitivity. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Mazor, Z., Brayer, L., Friedman, M., and Steinberg, D. Topical varnish containing strontium in a sustained-release device as treatment for dentin hypersensitivity. Olson, B. L., McDonald, J. L., Jr., and Stookey, G. K. The effect of strontium and fluoride upon in vitro plaque and rat caries. View abstract. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. Monitoring bone strontium intake in osteoporotic females self-supplementing with strontium citrate with a novel in-vivo X-ray fluorescence based diagnostic tool. 2007;18(12):1617-1624. According to the Michigan Health website: Compared with children with fewer cavities, enamel samples from children with high numbers of caries have been found to contain significantly less strontium. [3] Bartl, R. & Bartl, C.The Osteoporosis Manual: Prevention. Fed.Oper.Dent. 2007;357:nihpa40967. J Clin Endocrinol Metab 1966;26:566-72. Some antacids include calcium carbonate (Tums, others), dihydroxyaluminum sodium carbonate (Rolaids, others), magaldrate (Riopan), aluminum hydroxide (Amphojel), aluminum hydroxide/magnesium hydroxide combinations (Maalox, Mylanta), and others. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. 2008;9:165. Gillam, D. G., Bulman, J. S., Jackson, R. J., and Newman, H. N. Comparison of 2 desensitizing dentifrices with a commercially available fluoride dentifrice in alleviating cervical dentine sensitivity. View abstract. Bone 2009;45(2):200-206. The disease often progresses without any symptoms or pain, and is not found until bones fracture. 1980;51(10):578-581. Study design: Prospective animal model study. Calcium citrate is another of the more common calcium types used in calcium supplements. Schrooten I, Elseviers MM, Lamberts LV, et al. J Bone Miner Res 2008;23(S80). The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. View abstract. Strontium is similar to calcium. J Biol Chem 1972;247:5520-6. This could cause the body to have too much strontium and potentially cause side effects. Clin Nucl Med 2004;29:81-5. Contact Dermatitis 2000;42(2):98-100. Addy, M., Mostafa, P., and Newcombe, R. G. Effect of plaque of five toothpastes used in the treatment of dentin hypersensitivity. It can be found in soil and seawater as well as some foods. Currently, we do not have a way to measure the false increase in bone density that results when you take a supplement or a medication that includes strontium.. Hello @bonelady welcome to Connect. (17), In the 19th century, the first large scale use of strontium took place when it was employed to extract the sugar from sugar beets. Strontium results in an overestimation (up to 50%) of the increase in bone density using DXA methods.[3]. Reginster, J. Y., Seeman, E., De Vernejoul, M. C., Adami, S., Compston, J., Phenekos, C., Devogelaer, J. P., Curiel, M. D., Sawicki, A., Goemaere, S., Sorensen, O. H., Felsenberg, D., and Meunier, P. J. Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study. Scientists havent tested these supplements much, so theres not enough research to know if they fight osteoporosis. Over-the-counter dentifrices in the treatment of tooth hypersensitivity. About 99% of the strontium in the human body is concentrated in the bones. 2003;14 Suppl 3:S56-S65. Johnson, G. H., Bales, D. J., Gordon, G. E., and Powell, L. V. Clinical performance of posterior composite resin restorations. Select a condition to view a list of vitamins. View abstract. Osteoporos.Int. Glucosamine therapy for treating osteoarthritis. Calcium and strontium metabolic studies in patients on CAPD. That means it may affect how strong your bones are. Some years later in 1808, it was was isolated in its metallic formusing electrolysisby Sir Humphry Davy at the Royal Institution in London. 2000;57(3):1107-1114. Cochrane.Database.Syst.Rev. Cochrane Musculoskeletal Group. View abstract. This article will be helpful to you if you experience joint discomfort, especially from rheumatoid arthritis and other joint health disorders. 2014 Aug;53(8):1457-64. doi: 10.1093/rheumatology/keu018. 2012;23(3):1115-1122. doi: 10.1007/s00198-011-1847-z. New treatment strategies: ipriflavone, strontium, vitamin D metabolites and analogs. Leeb BF, Schweitzer H, Montag K, Smolen JS. View abstract. View abstract. [1] PRAC recommends suspending use of Protelos/Osseor. 2014. For more information:Sr-89 chloride side effects. 2006;34(8):608-613. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. Arthritis Res.Ther. Available at: www.servier.com/pro/osteoporose/protelos/protelos_spc.asp. In the human body, approximately 99 percent of Sr is located in the bones. Diagnosis and Management. Cancer that has spread to bone and causes pain. Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. (Accessed 01 August 2006). J.Thromb.Haemost. 9-25-2006;166(17):1899-1906. View abstract. Aluminum, iron, lead, cadmium, copper, zinc, chromium, magnesium, strontium, and calcium content in bone of end-stage renal failure patients. Although many people have never heard of it before, its a very interesting and somewhat controversial supplement. Reginster, J. Y. and Meunier, P. J. Strontium ranelate phase 2 dose-ranging studies: PREVOS and STRATOS studies. View abstract. It does not recommend it as a treatment for anyonewho has or has had heart or circulatory problems such as stroke, heart attack, or obstruction of the blood flow in the arteries. 2000;109(4):267-276. Maheu E, Mazieres B, Valat JP, et al. Chemical exchange between glass-ionomer restorations and residual carious dentine in permanent molars: an in vivo study. A double-blind, randomized placebo-controlled trial published in The Journal of Clinical Endocrinology and Metabolism looked at the effects of Sr on 261 men with primary osteoporosis.
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