hydroquinone solubility in glycerin hydroquinone solubility in glycerin

Data 51, 16681671 (2006), C. L. Yaws, S.-C. Lin, Enthalpy of fusion at freezing pointOrganic compounds, in Thermophysical Properties of Chemicals and Hydrocarbons, William Andrew Publishing (Elsevier, 2009), pp. Hydroquinone occurs in the environment as a result of anthropogenic processes, as well as in natural products from plants and animals. Data 51, 127129 (2006), J. Lim, S. Jang, H. K. Cho, M. S. Shin, H. Kim, J. Chem. Environ. Stir until uniform. Retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), which are protected have been shown to also be color stable in hydroquinone, magnesium ascorbyl phosphate and sodium metabisulfite composition at about a neutral pH, preferably from about 5.5 to about 8.0, more preferably from about 5.5 to about 7.5, and most preferably from about 6.0 to about 7.5. We have discovered that a hydroquinone composition (with about 1 to about 12% hydroquinone, preferably with about 2% to about 10%, more preferably with about 2% to about 8%, more preferably with about 2% to about 4%, most preferably with about 3% to about 4% hydroquinone) with preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, can include cationic salts of acidic ascorbyl esters, preferably sodium ascorbyl phosphate, more preferably aminopropyl ascorbyl phosphate, most preferably magnesium ascorbyl phosphate as an antioxidant and the color destabilization problems are appreciably less as compared to hydroquinone compositions without such a cationic salt of acidic ascorbyl esters in the neutral pH range: preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. Compositions according to this invention may include dermatologically acceptable carriers. Hydroquinone is 1,4-benzenediol. Correspondence to PubMedGoogle Scholar. Formula of hydroquinone is . I did that by using 1 cup of cream, 4tbsp of hydroquinone and 4tbsp of water or solvent. As utilized herein, the inhibition of the retinoid oxidation should be sufficient to prohibit browning of the composition for its shelf life, preferably greater than about six months, more preferably greater than about twelve months, and most preferably greater than about eighteen months. 0000004197 00000 n Chem. Azelaic acid (AzA) is a organic compound with the formula HOOC(CH 2) 7 COOH. stearic, palmitic, arachidic acids, Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. I'd like the consistency to be thin like a gel so that it absorbs quicker. 0000004433 00000 n Such carriers are widely known in the art and deliver the composition's ingredients to the skin without excessive degradation, inactivation or other unwanted interaction. Hydroquinone (C6H4(OH)2), also known as benzene-1,4-diol or quinol, is an aromatic organic compound, with a variety of uses in chemistry. uuid:a150f3fd-7f22-4439-aa26-6f445f4017e5 How to dissolve Hydroquinone to make 4 oz. Some hydroquinone compositions include antioxidants, such as ascorbyl palmitate. These phases (described below) are combined in a mixing tank with an in-line homogenizer as follows. For more information, please see our Retinoids are included in the invention from about 0.01 to about 5%, preferably from about 0.025% to about 2.0%, more preferably from about 0.05% to about 1%, and most preferably from about 0.025% to about 0.5%. [27] Several such agents are already available or under research,[28] including azelaic acid,[29] kojic acid, retinoids, cysteamine,[30] topical steroids, glycolic acid, and other substances. Chim. This study was funded by Ministre de l'Enseignement Suprieur et de la Recherche Scientifique. While the hydroquinone is effective for the pigmentation disorder treatment, retinoid is used for its skin treatment benefits. Hydroquinone can be made through several routes. The Molecular Weight is 110.11 g/mol. With respect to organic solvents, the solubility varies from 57% in ethanol to less than 0.1% in benzene. Hydroquinone compositions are effective but have some undesirable side effects. I've been presented with the problem of trying to dissolve Hydroquinone in a solvent other than water. [Na+].OC(=O)CC(O)(CC([O-])=O)C(O)=O.OC(=O)CC(O)(CC([O-])=O)C(O)=O, SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS, Preparations for care of the skin for chemically bleaching or whitening the skin, PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES, Medicinal preparations containing organic active ingredients, Acids; Anhydrides, halides or salts thereof, e.g. J. Pharm. Hydroquinone is highly susceptible to ring substitution by Friedel-Crafts reactions such as alkylation. Google Scholar, A.-C. Huang, Y.-K. Chuang, C.-F. Huang, C.-M. Shu, J. Therm. The reservoir opens through a muscle-controlled valve onto a thick-walled reaction chamber. Hydroquinone can lose a hydrogen cation from both hydroxyl groups to form a diphenolate ion. N')].uJr [23] This conclusion was reached based on the extent of absorption in humans and the incidence of neoplasms in rats in several studies where adult rats were found to have increased rates of tumours, including thyroid follicular cell hyperplasias, anisokaryosis (variation in nuclei sizes), mononuclear cell leukemia, hepatocellular adenomas and renal tubule cell adenomas. Production of Hydroquinone Industrial production of hydroquinone usually happens in two ways. HVoLg~Z+ 2017-02-16T10:10:56+01:00 Eng. Add the hydroquinone to the water. Other properties of hydroquinone are given in Table 1. Anal. Protected retinoid may be added to these compositions for additional skin benefit effects. . 114, 175188 (1996), I. Hahnenkamp, G. Graubner, J. Gmehling, Int. 38, 565571 (2006), K. Carlsson, B. Karlberg, Anal. 2017-02-16T10:10:56+01:00 0000005757 00000 n Table II shows that at 5C, 4% hydroquinone compositions maintain their white or light straw color with the addition of at least about 0.5% magnesium ascorbyl phosphate at the low pH ranges (from about 3.50 to about 5.50) and when about 1.0 to about 2.0% magnesium ascorbyl phosphate is used in the pH range of about 7.0. The present invention is not to be limited by any mechanism described in the specification, because it is defined by the claims. Examples of suitable methods of encapsulation include encapsulation by liposomes, wax, paraffin or any material or combination of materials which protect the retinoid from exposure to oxygen and inhibit oxidation of the retinoid from oxidation. One skilled in the art is familiar with the known protective system technologies, such as encapsulation and entrapment methodologies. 108. Preferably, the protected retinoid, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), is in the form of small beads or spheres suitable for incorporation into a topical composition. Retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), are beneficial for improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. It is highly soluble in water (70 g/litre at 25 C) and the log n-octanol/water partition coefficient is 0.59. The correlation coefficient is greater than 0.9937 for one of these two equations for the binary studied systems where the solvent is either water or 1-octanol. endstream endobj 382 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -558 -307 2034 1026 ] /FontName /BCGJCE+TimesNewRoman,Bold /ItalicAngle 0 /StemV 160 /XHeight 0 /FontFile2 389 0 R >> endobj 383 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 181 /Widths [ 250 0 0 0 0 0 0 278 333 333 500 0 250 333 250 278 500 500 500 500 500 500 500 500 500 500 333 333 0 570 0 0 0 722 667 722 722 667 611 778 778 389 500 778 667 944 722 778 611 778 722 556 667 722 722 1000 722 722 0 333 0 333 0 0 0 500 556 444 556 444 333 500 556 278 333 556 278 833 556 500 556 556 444 389 333 556 500 722 500 500 444 0 0 0 0 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 576 ] /Encoding /WinAnsiEncoding /BaseFont /BCGJCE+TimesNewRoman,Bold /FontDescriptor 382 0 R >> endobj 384 0 obj << /Type /FontDescriptor /Ascent 929 /CapHeight 0 /Descent -249 /Flags 32 /FontBBox [ -184 -249 1037 929 ] /FontName /BCGKAB+ImprintMT-Shadow /ItalicAngle 0 /StemV 0 /FontFile2 390 0 R >> endobj 385 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 122 /Widths [ 250 0 0 0 0 0 0 0 323 323 0 0 0 375 240 0 510 427 510 510 0 510 0 510 510 510 0 0 0 0 0 0 0 729 0 729 0 698 0 0 854 0 0 0 0 927 802 813 0 0 0 604 0 0 0 0 802 0 0 0 0 0 0 0 0 448 552 0 552 448 0 0 573 271 0 0 271 875 573 500 0 552 375 0 323 573 0 0 0 500 448 ] /Encoding /WinAnsiEncoding /BaseFont /BCGKAB+ImprintMT-Shadow /FontDescriptor 384 0 R >> endobj 386 0 obj << /N 3 /Alternate /DeviceRGB /Length 2575 /Filter /FlateDecode >> stream Antioxidants in the hydroquinone phase are instrumental in stabilizing the color of the hydroquinone composition. The protective system can be an entrapment system, a single or multi- laminar system, such as by the formation of vesicles such as a liposome or by utilizing wax, paraffin, silicone, polyethylene, or any material or system which protects the retinoid from oxidation. J. Chem. Bioaccumulative potential Hydroquinone (123 -31 -9) Bioaccumulative potential Not established. Gerhard Franz, Roger A. Sheldon "Oxidation" in. You take the cream, put it in a container, take the powder measurement and add it. Hydroquinone, like phenols are very weak acids and can be deprotonated. Google Scholar, W. J. Weber Jr, Y.-P. Chin, C. P. Rice, Water Res. Privacy Policy. The drug is freely soluble in water and in alcohol. It is a reducing agent that is reversibly oxidized to semiquinone and quinone. Retinoids are included from about 0.01% to about 5%, preferably from about 0.025% to about 2%, more preferably 0.05% to about 1.0%, and most preferably from about 0.025% to about 0.5%. You can expect to hear from a technical specialist within 1 business hour. Hydroquinone Safety Data Sheet according to Federal Register / Vol. You take the cream, put it in a container, take the powder measurement and add it. This page was last modified on 19 June 2019, at 20:05. They may also include ingredients with other therapeutic actions, such as anti-inflammatories, antibiotics, exfoliants and peels. Except where otherwise noted, data are given for materials in their, Hydroquinone oxidation with V2O5/NaClO3/H2SO4, http://www.sciencemadness.org/smwiki/index.php?title=Hydroquinone&oldid=11523, Articles containing unverified chemical infoboxes, GNU Free Documentation License 1.3 or later. The solubility in water is 6.72g/L. It would be desirable to combine the pigmentation disorder treatment with this skin benefit ingredient in one composition. Without being limited to the mechanism of this discoloration, it is believed that the discoloration may be caused at least in part by oxidation of the hydroquinone. Chem. Eng. ChemPoint will not under any circumstances release personal user information to individuals or companies. This saturated dicarboxylic acid exists as a white powder. These reactions release free oxygen and generate enough heat to bring the mixture to the boiling point and vaporize about a fifth of it, producing a hot spray from the beetle's abdomen. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. [Na+].OC[C@H](O)[C@H]1OC([O-])=C(OP([O-])([O-])=O)C1=O, N1=CC(C(=O)OCC)=CC=C1C#CC1=CC=C(SCCC2(C)C)C2=C1, C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21, CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C, disodium;2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate, [Na+]. Why we like it: This affordable cream contains 2 percent hydroquinone, sunscreen, and costs around five dollars. Approved only for prescription use in the U.S. market.Ideal for creams, lotions, and gels for personal care ingredients, pharmaceutical chemical, pharmaceutical excipients, and skin care ingredients. ORIGINAL CODE: 0009013, Ref document number: The color stability of the hydroquinone composition is promoted by one or more antioxidants in the hydroquinone phase, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate. Calorim. It has a white-solid appearance. International Journal of Thermophysics The document was not able to download due to an unknown error. M1 and M2 microemulsions contain ethanol as co-surfactant. If you are already a ChemPoint customer then sign up for access to our online ordering website. Then take the water and put the measurement into the microwave until boiled. Hydroquinone is a major benzene metabolite, which is a well-known haematotoxic and carcinogenic agent associated with malignancy in occupational environments. Thank you for your inquiry and interest in ChemPoint. The process of making a stable hydroquinone composition having a pH of about 5.5 to about 8.0 comprising: combining the following ingredients, in a carbon dioxide atmosphere: first, magnesium ascorbyl phosphate and sodium metabisulfite, then, third, magnesium ascorbyl phosphate, then, Application filed by Medicis Pharmaceutical Corp, [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O*, OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C, 3-aminopropyl [(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-yl] hydrogen phosphate, NCCCOP(O)(=O)OC1=C(O)[C@@H]([C@@H](O)CO)OC1=O, OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C, OC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C, trisodium;[(5R)-5-[(1S)-1,2-dihydroxyethyl]-2-oxido-4-oxofuran-3-yl] phosphate, [Na+].[Na+]. [24], Numerous studies have revealed that hydroquinone, if taken orally, can cause exogenous ochronosis, a disfiguring disease in which blue-black pigments are deposited onto the skin; however, skin preparations containing the ingredient are administered topically. HYdroquinone can be found in various skin care products. Reddit and its partners use cookies and similar technologies to provide you with a better experience. According to the polar paradox theory, this should lead to a dissolution of . 0000005089 00000 n 2 Liquid phase only; silicon dioxide remains as a residue in these solvents. Forms of retinoids have been developed wherein the retinoid is protected by a protective system. antiphlogistics and cardiaca, Cosmetics or similar toilet preparations characterised by the composition, Cosmetics or similar toilet preparations characterised by the composition containing inorganic ingredients, Sulfur; Selenium; Tellurium; Compounds thereof, Cosmetics or similar toilet preparations characterised by the composition containing organic compounds, Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen, . I'm using it for spot treatment of some hyper pigmentation (less than 1% of my body). Gravimetric method is used to measured hydroquinone solubility in water, ethanol and in water+ethanol binary mixtures at temperatures (293.15, 295.15, 298.15, 300.15, 303.15, 305.15, 308.15, 310.15 and 313.15)K. Mole fractions solubility of hydroquinone are correlated with temperature by using the Apelblat equation. Hydroquinone is considered to be readily biodegrable and photodegradable. Some documentation and label information may refer to the legacy brand. How do I dissolve hydroquinone powder to make a 20% and 10% concentration? Read our Privacy Notice. Tests, which results are detailed in the following two tables, are performed at 5C and 40C for certain percentages of magnesium ascorbyl phosphate at specific pHs. The amount of crosslinking was controlled by the reaction conditions, including temperature, reaction time, and . The preferred protected retinoid is in the form of small beads or vesicles which are of a form that can be adjusted to be incorporated into varied topical compositions. The solubilities of benzoic acid, salicylic acid, resorcinol and hydroquinone in water and in 1-octanol were measured by the dynamic method which is also called the synthetic method from 297.25K to 334.45K. Using differential scanning calorimetry (DSC Q2000 and SDT Q600), the melting temperature and the enthalpy of fusion of these solutes were determined. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Toxicol. Canon 0.6. glycerin, 2.5. Some may double boil the hydroquinone and ester, I was too scared of the possibility of combustion. The FDA had classified hydroquinone in 1982 as a safe product - generally recognized as safe and effective (GRASE), however additional studies under the National Toxicology Program (NTP) were suggested in order to determine whether there is a risk to humans from the use of hydroquinone. This is a preview of subscription content, access via your institution. Found. It is understood that while the invention has been described in conjunction with the detailed description thereof, that the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims. x- [ 0}y)7ta>jT7@t`q2&6ZL?_yxg)zLU*uSkSeO4?c. R -25 S>Vd`rn~Y&+`;A4 A9 =-tl`;~p Gp| [`L` "AYA+Cb(R, *T2B- 0000003660 00000 n 76/768/EEC:1976 Council Directive 76/768/EEC of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products: Organic Chemistry, Solomon and Fryhle, 10th edition, Wiley Publishing, 2010. Hydroquinone is a white crystalline solid, poorly soluble in water, but more soluble in organic solvents. Preparation, optimization and in vivo. The experimental solubility data was well-correlated with the data, calculated by . Other aspects, advantages, and modifications are evident from a review of the following claims. wG xR^[ochg`>b$*~ :Eb~,m,-,Y*6X[F=3Y~d tizf6~`{v.Ng#{}}jc1X6fm;'_9 r:8q:O:8uJqnv=MmR 4 This range of pH has been preferred for hydroquinone compositions, because it has been believed that the hydroquinone is less likely to excessively discolor under acid conditions. [21] The FDA officially banned hydroquinone in 2020 as part of a larger reform of the over-the-counter drug review process. Chemically, hydroquinone is designated as p-dihydroxybenzene; the empirical formula is C 6 H 6 O 2; molecular weight is 110.0. 20grams ofhydroquinonein 20oz is liquid is 10%. We will respond to you shortly. J. The solubilities in binary and ternary systems of hydroquinone (1,4-dihydroxybenzene) and p-quinone (1,4-benzoquinone) in supercritical carbon dioxide were measured in the pressure range 10.0 to 35.0 MPa at temperatures of 333, 348 and 363 K.In binary systems, the solubility of hydroquinone was three orders of magnitude lower than that of p-quinone. This compound is gathered from the beaver's castor sacs.[35]. Water Solubility 73000 mg/L at 25C 2.6B pH pKa 4.0 - 4.7 pK1 = 9.9 2.12 Oxidation:Reduction Potential +286 mV at 25C and pH 7 ENVIRONMENTAL FATE/BIODEGRADATION 420, 2429 (2016), W. E. Acree Jr, Thermochim Acta 189, 3756 (1991), F. L. Nordstrm, . C. Rasmuson, J. Chem. It exerts a depigmenting effect on skin of mammals by increasing the excretion of melanin from the melanocytes. HyTSwoc [5laQIBHADED2mtFOE.c}088GNg9w '0 Jb Res. 2008-2023 ChemPoint. Anal. This invention relates to methods and compositions for the treatment of pigmentation disorders, including hyperpigmentation and vitiligo. A common route involves hydroxylation of phenol. ADS Retinoid compositions, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) are known to be effective in improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. Hydroquinone occurs as fine, white needles. Approximate Solubilities of USP and NF Articles, methanol, 13; ethyl acetate, >10,000; hexanes, >10,000, 0.1 N hydrochloric acid, 1; 0.1 N sodium hydroxide, 1, boiling alcohol, 50; boiling chloroform, 80; acetone at 50, methanol, 3; isopropanol, 69; benzene, 2500; petroleum ether, 5000, dimethylformamide, 10; 10 N sodium hydroxide, 3.5, dimethylacetamide, 2; dimethylformamide, 3.5; dimethylsulfoxide, 3.5, 0.1 N hydrochloric acid, 2500; 0.1 N sodium hydroxide, 100, isopropyl alcohol, 4; propylene glycol, 9; methanol, 5.3, isopropyl alcohol, 1408; propylene glycol, 119; methanol, 75, alcohol solution (1 in 2), 2; diethylphthalate, <1; benzyl benzoate, <1, acetone, 100; methanol, 1000; 0.1 N hydrochloride acid, >1000, absolute alcohol, 8; methanol, 8; propylene glycol, 19, pyridine, 10; methanol, 71; acetone, 130; methylene chloride, 286; toluene, 2000; dioxane, 2000, carbon disulfide, 2 (slowly and usually incompletely), carbon disulfide, 2 (slowly and usually incompletely) olive oil, 100, methylenedichloride, 43; 4-methyl-2-pentanone, 100. Some documentation and label information may refer to the legacy brand. 38, 40814091 (1999), J. Qingzhu, M. Peisheng, Y. Shouzhi, W. Qiang, W. Chang, L. Guiju, J. Chem. 20, 14331442 (1986), G. Wienke, J. Gmehling, Toxicol. Polysorbate 20 0.5% 0.15g. Then take the water and put the measurement into the microwave until boiled. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. 330, 4851 (2012), A. Shalmashi, A. Eliassi, J. Chem. Hydroquinone Revision Date 24-Dec-2021 General Advice If symptoms persist, call a physician. The present invention addresses the problem of excessive discoloration in hydroquinone compositions of a neutral pH. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. EP, Kind code of ref document: D-170D Solubility of EASTMAN Hydroquinone and Derivatives Subject: Hydroquinone and hydroquinone derivatives listed in this publication are used as intermediates for manufacturing a variety of products and as polymerization inhibitors for vinyl monomers and unsaturated polyester resins. Johnson & Johnson Consumer Products, Inc. Johnson & Johnson Consumer Companies, Inc. AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR, STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN, Color Stability of 4% HQ Compositions with varying pH and % Sodium Metabisulfite at 5C and 40C, Color Stability of 4% HQ Compositions with varying pH and % Magnesium Ascorbyl Phosphate at 5C and 40C, Polyacrylamide (and) C 13-14 isoparaffin (and) laureth-7, Water, Soybean (Glycine Soja) Oil, Carnauba (Copemicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Water, Soybean (Glycine Soja) Oil, Carnauba (Copernicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Compositions for the treatment of pigmentation disorders and methods for their manufacture, Stabilization composition including hydroquinone or derivative thereof, Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof, Depigmenting composition for the skin comprising adapalene and at least one depigmenting agent, Depigmenting composition for the skin, use of a depigmenting composition for the skin, cosmetic use of the same and method for non-therapeutic cosmetic treatment, Cosmetic designs and products using intronic RNA, Holistic composition and method for reducing skin pigmentation, Topical compositions and methods of manufacturing them in specifically treated steel vessels, System for improved percutaneous absorption of skin benefiting agents, Discontinuous surface coating for particles, Method of treating skin requiring chemical peel procedure, Method of treating skin needing hyaluronic acid treatment, Method of treating skin having incision from surgical procedures, Method of treating skin requiring hair removal procedure, Method of treating skin requiring Intense Pulse Light (IPL) procedure, Method of treating skin subject to or affected by aesthetic surgical procedures, Method of treating skin needing ablative treatment, Method of treating skin requiring radiofrequency procedure, Method of treating skin requiring non-ablative procedure, Method of treating skin requiring fractional resurfacing treatment, Method of treating skin needing botulinum toxin type a treatment, Method of treating skin requiring microdermabrasion, Method of treating skin needing collagen treatment, Method of treating skin requiring skin cancer treatment, Methods of treating skin to enhance therapeutic treatment thereof, Ras mutation and compositions and methods related thereto, Compositions, kits and regimens for the treatment of skin, especially dcolletage, Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions. Eng. InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H, InChI=1/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H, Except where otherwise noted, data are given for materials in their. Solubility of Hydroquinone. Fill out the form below, and we will send you the document as soon as we can!