government site. Increases the relative proportion of some key beneficial groups: Clostridia (butyrate producers), Bifidobacteria, possibly Lactobacilli, Berberine can also inhibit Candida and other potential opportunistic pathogens and parasites, It can cause an initial broad-spectrum reduction in microbiome, similar to antibiotics, It may reduce the overall diversity of the microbiome, also similar to antibiotics. She ate her way back to health using a Paleo diet, lost 80 pounds, and had a healthy baby after numerous miscarriages. Eat . The benefit of berberine is that it selectively kills only the "bad" bacteria and has no adverse effect on "good" bacteria, thereby allowing the healthy microbiome to be restored. I have 2 lesions on my chin that biofilm is keeping from healing for over 2 years. You should notice results within 2-4 weeks of improved symptoms and less inflammation. Next, steps need to be taken to disrupt and kill the underlying pathogen that formed the biofilm. Garlic is a powerful broad-spectrum anti-pathogenic food. It is also often combined with other herbs such as echinacea. Although berberine appears to be safe and cause few side effects, a person should speak with a doctor before taking it. It may be as effective as some pharmaceutical drugs. One of the main actions of berberine is to activate an enzyme inside cells called AMP-activated protein kinase (AMPK), according to some animal studies (3, 4). I thought that pathogens that are enveloped in biofilm dont show up in these tests. Sorry to hear this! An older but often-cited May 2008 study in Metabolism looked at a relatively small sample size of 36 adults newly diagnosed with type 2 diabetes who were treated with either berberine or metformin (both three times per day) over the course of three months. Its in my wood floors. However, scientists need to conduct more large, double-blind studies to fully determine berberines safety and efficacy. National Library of Medicines list Berberine is antimicrobial, making it great for the digestive system and microbiome. It lowers cholesterol and may reduce your risk of heart disease. PCOS, or polycystic ovarian syndrome, is one of the leading causes of fertility problems in women. Given that proper microbial diversity in the gut is absolutely critical for mental and immune health, you simply cannot experience optimal health without it. I also take cranberry. A typical dose of enteric-coated peppermint oil is one to two capsules three times a day. What would you suggest to break down this biofilm? 4. Berberine has been shown to help lower blood sugar and HbA1c. The https:// ensures that you are connecting to the Conditions like leaky gut or the presence of a foreign pathogen in the digestive tract can drastically interfere with a persons health. Many factors that can be measured in the blood are associated with an increased risk of heart disease. The health benefits of berberine are numerous. Dehau T, Cherlet M, Croubels S, van Immerseel F, Goossens E. mSystems. Another review of 12 studies found that supplementing with berberine led to significant reductions in body weight, body mass index, and belly fat. Its uncomfortable, and annoying. Doctors havent been of help. If you liked that article, you'll absolutely LOVE our daily newsletter -- with more recipes, workouts, and tips and tricks to be the healthiest version of yourself. For instance, a July 2020 systematic review in Biomedicine & Pharmacotherapy on the effect of berberine on weight loss found that berberine can help prevent obesity in a few different ways: by changing the genes that make the body store fat, helping to stop the growth of fat in the body by encouraging enzymes that activate glucose and fatty acid uptake and regulating gut hormones, which also impact weight and insulin resistance. Scientists say that berberine and metformin share many features, and both could be useful for treating type 2 diabetes. Would it hurt to add in some apple cider vinegar, MCT oil, oregano, and garlic, along with your protocol? Berberine is a well-studied supplement with a host of beneficial possibilities. Heart disease is currently the leading cause of death around the globe (17). Please, how do I start the protocol? I went to, would not come near me or even look at my skin after hearing about my symptoms. I don't know, but most believe in the good bacteria theory. HHS Vulnerability Disclosure, Help In my case do you think its better to use everything at the same time or dividing on intervals? (12, 13) When compared to medications aimed at lowering both systolic and diastolic levels, berberine wins. PCOS While studies in humans and rodents have suggested this could be true, scientists caution that more research is needed to confirm how berberine affects humans and whether it is safe to use. Berberine is a very effective supplement chemically derived from different plants such as goldthread, goldenseal, Phellodendron, and many others. i have a body odor that smells like i passed gas would this be biofilms from leaky gut syndrome? In the sinuses, it is good to use the Ion Sinus spray as well. I like using the Organic Turmeric which has other great biofilm busting ingredients such as ginger and cumin. (22). 2023 Jan 13;137(1):65-85. doi: 10.1042/CS20220697. I am having an outbreak of 1 1/2 months duration of bleeding ulcerative colitis. Therefore, the overuse of oregano essential oil can lead to diarrhea and an upset stomach. Berberine Complex: these herbs are also found in the Metagenics formula. Yes biofilms may be playing a role in this. I can highly recommend to you the Source Naturals D-Mannose, which is flavorless and easy to take. Epub 2017 Feb 10. This, in turn, helps lower total cholesterol and triglyceride levels. In particular, berberine has been shown to lower blood sugar, increase weight loss, and improve heart health. We live in an amazingly fast-paced society that makes ground-breaking advances in science almost constantly. Always seek the advice of a licensed, qualified healthcare practitioner before acting upon any information provided herein. Another great biofilm disruptor is the ancient tonic, apple cider vinegar. Seven herbal medicines can kill Lyme disease bacteria in test tube Researchers have determined that seven herbal medicines are highly active in test tubes against B. burgdorferi, the bacteria that causes Lyme disease, compared to the control antibiotics, doxycycline and cefuroxime. This is why berberine is a key ingredient in my GI Clear that I use with all of my patients who are trying rid themselves of pathogens in the digestive tract. The lab I like to use the most is called the GI MAP Stool Analysis which is very good for picking up pathogens such as H Pylori and parasites as well as problematic bacteria. In animal studies, scientists have noticed the following effects, depending on the type of animal, how much they consumed, and for how long: It is essential to speak with a doctor before taking berberine or other supplements, as they may not be safe or suitable for everyone to use. The Memorial Sloan Kettering Cancer Center notes that berberine may be most effective in people who have mild cases of high cholesterol, but it won't take the place of healthy, cholesterol-lowering lifestyle habits like getting regular exercise and eating nutritious food. Technically, berberine is a bioactive compound extracted from several. Hey Hankg, I recommend the biofilm protocol before the test. First, you need to physically breakdown or dissolve the biofilm. Theres an SSKI kit on amazon made by morgellons direct. Here are seven of the most effective ways to use berberine to boost your health. I am not sure how you would get these in China but you should look for these similar ingredients at your health food store. The acetic acid in apple cider vinegar has been shown to kill unwanted bacteria while also cutting through mature biofilms in chronic infections ( 5 ). Chen H, Zhang F, Li R, Liu Y, Wang X, Zhang X, Xu C, Li Y, Guo Y, Yao Q. Biomed Pharmacother. Short-term BBR exposure altered intestinal bacteria by reducing Clostridium cluster XIVa and IV and their bile salt hydrolase (BSH) activity, which resulted in the accumulation of taurocholic acid (TCA). We now know that many pathogens adhere to the lining of the gut, colonize, and form a protective barrier around themselves called a biofilm. Berberine can cause digestive side effects, such as: It can also cause a rash or headache in some people. Another option is the Complete Digestive Health Analysis. Berberine has a large impact on the microbiome: Large initial reduction overall, by inhibiting bacterial cell division. Inflammation is a key factor in several health conditions, including heart disease and diabetes. This stuff embeds in your clothes, shoes, coats. Prunes and prune juice have many health benefits. Another 2013 study found that out of 35 different compounds observed, curcumin landed itself as one of the top six biofilm-disrupting agents (4). When yeast dies it releases a host of lousy poisons, notably Acetaldehyde. Several workers have reported varied pharmacological properties of these alkaloids as they exhibit antibacterial, antiasthma, anticancer, anti-inflammatory, and antidiabetic activities. The main side effects are related to digestion, and there are some reports of diarrhea, constipation, and bloating (33). The answer is probably way too many. GI Clear also contains other anti-microbial and anti-biofilm herbs such as artemisinin, tribulus and black walnut powder. Is it something I will know is happening? Berberine (BBR), a natural plant alkaloid, is the major pharmacologic component in the Chinese herbal medicine Coptis chinensis (Huang-Lian) ( Tang et al., 2009 ). Something that has not been fully understood for a long time is why some GI disorders are so tough to get rid of. Berberine has an antibacterial action that seems to remove the harmful bacteria in the gut, and thus enhance the growth of healthy bacteria. However, more research is needed to show that it is safe to use as a treatment option. Chinen salt is a compound often used in Traditional Chinese Medicine (TCM). LOW levels of Faecalibacterium prausnitzii and Secretory IgA were noted, as well as occult blood and inflammation. I have inflammation on prostate.actually the microbe is klebsielaCan i follow the program along to antibiotics?If yes, which is the order(e.g. By using DrJockers.com or by clicking to accept or agree to Terms of Use when this option is made available to you, you accept and agree to be bound and abide by the Privacy Policy. Reduction in lipids, particularly cholesterol, is achieved partly through up-regulation of bile acid synthesis and excretion into the gastrointestinal tract (GI). Medical studies document that Berberine is an anti-parasitic agent that treats some of the most prevalent and aggressive parasites in the world. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. Berberine stops diarrhea caused by cholera 11. Dr. Jockers, It helps with glucose metabolism, maintenance of healthy lipid levels (LDL & HDL cholesterol), improves insulin sensitivity, helps lower blood pressure, weight management, the immune system, and boosts cognition. Some candida mutations have developed resistance to fungal drugs, but berberine has the same action against drug resistant strains. Many of the studies cited in the article used dosages in the range of 5001500 mg per day. It may also help reduce androgen levels, which can improve ovulation, according to The National Polycystic Ovary Syndrome Association. Is the ketogenic diet right for autoimmune conditions? Learn more here. DR. Jockers, Thank-you for sharing all this info. Phosphorous. 5 Vibrations? P1. Pharmaceutics. Berberine also appears to inhibit the growth of fat cells at the molecular level, which could help promote weight loss (16). Any thoughts? Berberine has a large impact on the microbiome: Large initial reduction overall, by inhibiting bacterial cell division Negative effect on many potential pathogens: Proteobacteria (E. coli, Shigella, Salmonella, Klebsiella, Proteus, Vibrio), Staphylococcus, etc. It's also been reported that berberine can raise HDL, the "good" cholesterol. All this talk about biofilms may sound disconcerting so far but, now that we know about them, this information is actually quite empowering. Green leafy vegetables contain a special kind of carbohydrates that supplies good bacteria with food. border: 1px solid #e5e597; Thanks to our developing understanding of pathogens and biofilms, eradicating stubborn and once hidden infections from the body is now possible. Sometimes, I will have body Vibrations in my scalp, central face around nose and eyes. If I take a 1 or 3 day Monistat will this interfere with any of the pills? Do you have any suggestions or a protocol for eliminating Klebsiella from gut in regard to Ankylosing Spondylitis flare ups? Yes this can happen and the protocol will help immensely. I recommend that if you have any specific concerns to consult with your physician. Another study, published July 2012 in Phytomedicine, confirmed that berberine can be helpful for weight loss: Study participants lost an average of 5 pounds after taking 500 milligrams of berberine three times a day for 12 weeks. We do not aim to diagnose, treat, cure or prevent any illness or disease. Habtemariam, S. (2020). Normally, the small intestine is almost sterile, only populated by select bacteria in very small numbers. Many studies show that berberine can significantly reduce blood sugar levels in individuals with type 2 diabetes (8). Williamson says the following recommended dosages have been based off various studies: Note that you should always talk to your doctor first before adding any supplement to your regimen. Accessibility In vitro, isolated mouse cecal bacteria were incubated with three doses of BBR (0.1, 1, and 10 mg/ml) for 4 hours in an anaerobic chamber. However, if a persons doctor has prescribed metformin, they should not consider berberine as an alternative without first discussing it with their doctor. It is a very safe dietary supplement and natural plant extract. This is when toxins are dumped partially from one area of the body but then begin to reabsorb if not properly removed. Thank you! A High Dose of Dietary Berberine Improves Gut Wall Morphology, Despite an Expansion of. The participants also lost 3.6% of their body fat (14). The accumulation of TCA was associated with activation of intestinal FXR, which can mediate bile acid, lipid, and glucose metabolism. I am Canadain but i live in a small town in south of France. Speak with a doctor before taking berberine for diabetes. It may not be right for everyone and could interact with other medications. Along with the solution of one problem comes the discovery of a new problem. Unable to load your collection due to an error, Unable to load your delegates due to an error. I suspect I may have a thyroid condition as a result of the blasto. Treats SIBO (increase in the number of bacteria in the stomach) Many people turn to natural and alternative treatments for gastrointestinal problems, and a good reason. It is often recommended based on the results of functional stool testing of microbiota populations, where berberine is a suggested agent to decrease dysbiosis, be it fungal or bacterial. Polycystic ovary syndrome (PCOS) occurs when a female has high levels of certain male hormones. And if so, how (when take what)? On day 2 of your protocol & constipated. PMC In order to effectively remove a biofilm from the body, a multi-directional approach is needed. Hi Sally, I would recommend trying to include oregano into your regular diet. According to an older review of 14 studies, berberine may be as effective as certain oral diabetes drugs, including metformin, glipizide, and rosiglitazone (12). Berberine may also have numerous other health benefits: Many of these benefits need more research before firm recommendations can be made, but the current evidence is very promising. (8) It not only treats diabetes itself, but the serious complications of this disease as well, like nerve problems, slow wound healing, and even stroke. (9), Specifically, berberine helps diabetes by increasing the ability of cells to take in glucose, lowering the amount of circulating glucose, dropping blood sugar levels, and improving insulin sensitivity. Started taking NAC 2 months ago and the last 3 weeks have been horrible. i am so weak, ill, sad, angry, nonstop thinking about what to do to get health! Quorum sensing is how bacteria communicate, evaluate their surroundings, and decide the perfect moment to spread (8). I have morgellons. When is the best time in this protocol to also add probiotics? Now, modern science has confirmed that it has impressive benefits for several different health problems (2). I recommend finding a functional health practitioner that will help get to the root cause of your problems and customize a specific plan for you! What to Know Before You Try Bitter Melon for Diabetes, Yacon Root: Health Benefits & Side Effects, National Center for Complementary and Integrative Health, The National Polycystic Ovary Syndrome Association, Evidence-Based Complementary and Alternative Medicine, Memorial Sloan Kettering Cancer Center: "Berberine", National Center for Complementary and Integrative Health (NCIH): "Goldenseal", Metabolism: Efficacy of Berberine in Patients with Type 2 Diabetes, Science China Life Sciences: Learning from berberine: Treating chronic diseases through multiple targets, Clinical Microbiology: Berberine: A Medicinal Compound for the Treatment of Bacterial Infections, Chronic Diseases and Translational Medicine: Study progress of berberine for treating cardiovascular disease, Clinical Lipidology: Metabolic and cardiovascular effects of berberine: From preclinical evidences to clinical trial results, Biomedicine & Pharmacotherapy: The effect of Berberine on weight loss in order to prevent obesity: A systematic review, Phytomedicine: Lipid-lowering effect of berberine in human subjects and rats, Evidence-Based Complementary and Alternative Medicine: "Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis", The National Polycystic Ovary Syndrome Association: "Popular Supplements for PCOS". Thank you! In a May 2014 study conducted on mice in Clinical Microbiology, researchers found giving a berberine supplementation for 14 weeks significantly decreased inflammatory markers and helped protect the spleen, liver and kidney from the effects of chronic inflammation. The few Berberine side effects include mild gastrointestinal discomfort at high doses. When taken as recommended, berberine produces little or no side effects, but when taken in higher doses, it can cause nausea and constipation. Yellow root is a small plant with a hairy stem, jagged leaves, small flowers and raspberry-looking fruit, and it contains a small amount of berberine. This tissue helps the body turn food into body heat, and increased activation may help treat obesity and metabolic syndrome. The side effects that can occur with berberine are overall pretty mild, but can include: However, always be sure to talk to your doctor before taking berberine or yellow root because it can interfere with certain conditions and medications. sharing sensitive information, make sure youre on a federal This is the only single use herb that's been studied with SIBO, and was found to be effective for methane-dominant SIBO. Berberine is also used in traditional Chinese medicine and has been studied for its potential benefits for heart health, lowering blood sugar and use as an antibacterial. I recommend the Para 2 here: https://store.drjockers.com/products/para-2. doi: 10.1128/msystems.01239-22. Particularly serratiopeptidase and trypsin have been studied for the ability to mitigate the formation of biofilms after orthopedic surgery, a potentially dangerous complication (11). The benefits of berberine include being good for your gut and helping to control sugar cravingsto name just a couple. Berberine, on the other hand, has been reported to cause cytotoxicity and adversely influence the synthesis of DNA. dataLayer.push({'eventCategory': 'leadbox', 'eventAction':'show', 'eventLabel':'Digestion Guide Lead Magnet', 'nonInteraction':'Yes'}); Early research suggests that using eye drops containing berberine and tetrahydrozoline . Natural oregano oil contains the highest concentration of carvacrol compared to other herbs. It seems to have anti-fungal, anti-bacterial effects amongst other things. What does passing destroyed biofilm look like? Also strange things like dead fingertips with cold weather. Can poor sleep impact your weight loss goals? Some research suggests that berberine works similarly to the drug metformin, which doctors often prescribe to treat type 2 diabetes. Berberine, a compound found in certain plants, is known for its deep yellow color and has frequently been used throughout history as a natural dye for wood, leather and wool. Hi, just to mention that Candida is not a bacteria as mentioned in teh friendly/unfriendly bacteria. Aimee McNew is a Certified Nutritionist who specializes in women's health, thyroid problems, infertility, and digestive wellness. Berberine has been used to treat obesity, diabetes mellitus, atherosclerosis, and metabolic diseases in China. reduce bacterial, yeast and parasitic overgrowths and support overall digestive and immune health. Research has shown that berberine may work as a diabetes treatment. If youve been feeling down lately, berberine may be able to help. Berberine, or berberine hydrochloride, is a compound in several plants, including goldenseal, barberry, Oregon grape, and tree turmeric. The GI Map Stool Analysis is a fantastic test for overall gut health. Hello I was wondering how much garlic and oregano oil to take? Berberine has been shown to help lower blood sugar and HbA1c. What would the antimicrobial protocol using antimicrobial herbs and charcoal consist of? I hope you can help with some of these questions. If I touch anything with biofilm I get a numbness tingly feeling instantly. You can find details here: https://drjockers.com/functional-nutrition-tips-to-find-a-great-health-coach/. Last medically reviewed on February 21, 2023. Berberine may interfere with other medications, such as metformin. However, the AANP urges people to speak with a doctor before taking berberine to check that it is safe to use and how much they can take. Can it be possible to have a biofilm inside the vagina? 3 Clothes. However, there is not enough information to show that long-term use is safe. 1,2,10-14,22 On this basis, contemporary herbalists often use goldenseal as a topical antibiotic for skin wounds, as well as to treat viral mouth sores and superficial fungal infections, such as athlete's foot. In particular, berberine can help to destroy the ulcer-forming bacteria H. pylori when taken twice daily for six weeks. Bookshelf The gastrointestinal microbiota is a multi-faceted system that is unraveling novel contributors to the development and progression of several diseases. Would you like email updates of new search results? I would recommend working with a functional health coach to get to the root cause: https://drjockers.com/functional-nutrition-tips-to-find-a-great-health-coach/. ( 21) 5. How much berberine you should take depends on what you want it to do for you. What could be done about thiscolon hydrotherapy? Berberine alters gut microbial function through modulation of bile acids. It detects parasites, gut imbalances, H Pylori, and much more. I personally eat fresh oregano almost every day in my foods. The products mentioned in this article may be helpful. Although more research is needed on acetic acid for this effect, apple cider vinegar can be a . According to the Science China Life Sciences review, there hasn't yet been a large-scale, randomized, double-blind clinical trial on how berberine can lower cholesterol, but the researchers pointed to a number of independent groups that have documented this effect. Berberine for PCOS: Benefits, Side Effects, and Dosage, 9 Impressive Health Benefits of Barberries. There could be an association but certainly cannot say that is the cause. This article takes an in-depth look at berberine, how it works, and how it can impact your health. first antimicrobial then antibiotics etc.) Metabolism. They gave her another round to treat it & no help. Sincerely- Becca, So sorry to hear about this Becca! Dr. Jockers, Hello! A more accurate descriptor would probably be dysbiotic flora thanks for pointing that out! Hi Carmie, Sorry to hear about that! 13. What can we do for our dogs and cats? Rebuild "good" bacteria in your gut with probiotic-rich foods such as yogurt. 2021 Mar;49(3):276-286. doi: 10.1124/dmd.120.000215. Yes, you can set an appt with Dr Jockers by contacting his clinic Exodus Health Center https://drjockers.com/clinic/. Unauthorized use of these marks is strictly prohibited. 9. 2960 Inca St. Suite 206 A recent study found berberine effective against drug-resistant candida. They include: Berberine has been found to help regulate blood sugar and lipid metabolism. Clin Sci (Lond). Heart disease is a major cause of death. People should speak with their doctor before taking products containing berberine. Cancer cells have a protein matrix on their outer layer so proteolytic enzymes can help to metabolize this: https://drjockers.com/systemic-enzymes-powerful-immune-support/. My throw rugs. Goldenseal side effects. There are so many herbs to choose from that it's easy to rotate through different antimicrobials across treatment rounds to avoid resistance. Again, though, this study was done in rodents, so we don't know if berberine would have the same effect in humans. It is not always clear how much of an active ingredient is present in a supplement, which could lead to taking the wrong dose. Do you suggest doing the Heavy Metal detox first or the biofilm protocol listed above for gut issues like lymphocytic colitis? Keep in mind that diabetes, high blood sugar levels, and obesity are also major risk factors for heart disease, all of which seem to be improved with this supplement (7). How would this work with something like Cosevas Advance TRS? This could be things like bad bacteria, viruses, parasites, or fungus that make a home along the walls of the stomach and intestines. Hey Kara, I am sorry to hear this! (4) It can also be used to fight other types of bacteria and fungi, such as staph and candida. Hey Jae, maybe this info will be helpful for you: https://drjockers.com/heal-utis-naturally/. Healthline Media does not provide medical advice, diagnosis, or treatment. After the 14 days recommended above, you would probably want to use ongoing anti-microbial support. Anyone who develops an allergic reaction to any herbal product should stop using it at once. Before . As it turns out, berberine has been shown to improve many of these factors. I think I am going to try your protocol. Any suggestions? I wonder if when the odor stops being so strong thats an indicator that the biofilms are destroyed. 2020 Apr;124:109829. doi: 10.1016/j.biopha.2020.109829. eCollection 2022. As such, people should use it with care and speak with a doctor before taking it. For bacteria, this is an important survival mechanism. 2 Enviornment. And certain the biofilm is preventing the healing. what am i doing wrong? They will develop resistance. Some research suggests that it may help promote weight loss, enhance blood sugar control, and protect against several chronic conditions. Sometimes it can look like a mucousy film, but not always! Researchers believe this activation can help treat diabetes and related health issues, such as obesity and high cholesterol. While activated charcoal isnt directly involved in breaking up biofilms, it is a crucial step in a biofilm-breaking protocol. The National Center for Complementary and Integrative Health (NCCIH) notes that if adults take goldenseal, which contains berberine, by mouth it is unlikely to cause severe adverse effects in the short term. In other words, it eliminates all types of bacterias, the good and the bad ones in your gut. So no probiotics while taking a biofilm disruptor? This article reviews all you need to. Garlic is an herb known for its taste and prebiotic properties. I would recommend a full digestive health restoration program with antimicrobial herbs and essential oils as part of the program: https://drjockers.com/the-digestive-health-restoration-program/, I have been coughing , choking up bio film for 4 mos. I have been taking your CBD Cologne for over 3 years for joints and skin, etc. and transmitted securely. Oregano oil has worked in the past, but it works very slowly (perhaps due to dose?). Here, we examined the effect of berberine (BBR), a natural plant alkaloid, on intestinal bacteria using in vitro and in vivo models. As always, speak with your doctor before adding a supplement to your health routine. , Could biofilm be the reason behind chronic UTIs from E. coli? This enzyme plays a key role in regulating metabolism and energy levels and is found in the cells throughout the body (5, 6). (14), While berberine is far from a miracle weight loss drug, research shows that it can help lead to weight reduction in those with obesity. In vivo, the metabolomic response and changes in mouse intestinal bacterial communities treated with BBR (100 mg/kg) for 5 days were assessed using NMR- and mass spectrometry-based metabolomics coupled with multivariate data analysis. Take Berberine and Oregano oil 30 minutes before breakfast and dinner. It works in the body in multiple ways and is able to make changes within the bodys cells.
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