Thanks. I have just read in some other histamine intolerance articles elsewhere that green tea is a potent anti-inflammatory and inhibitor of the histamine producing enzyme. Then add 1 1/2C milk and stir until combined. Would love to hear what you think. It cant be good for you but has to better than fried, right? 5 milligrams of potassium. Egg yolks have no effect on me, I can eat yolks lightly poached/soft. Sometimes, however, mast cells show up in excess (a rare condition known as mastocytosis), or, as in MCAS, they overproduce these pro-inflammatory molecules, flooding the system with them and mimicking an allergic response. Each person is different, you have to find out what works for you. Too much histamine is inflammatory. Your reaction to maple syrup may be different than someone else's. I would like to know more of the molecular science behind why it works. HISTAMINE AND ALLERGIES In my functional nutrition practice, I often hear the following: I am having allergic reactions, but the doctor says I dont have any allergies. People come in with hives or red itchy bumps or breathing troubles, but with no identifiable true allergies. Alcohol-free vanilla and other extracts are also allowed. Here are the best sweetener options for low histamine diet adherents: Keep in mind that the histaminic impact of many of these sweet substances lies in the blood sugar component. Caution with sugar alcohols such as xylitol (which can cause gas in those with compromised gut health). Unlike with histamine intolerance patients, it is imperative that MCAS patients implement a strict low-histamine diet (provided their diet is not already too restricted) and otherwise employ the same interventions that we use for histamine intolerance. 10. https://www.amazon.com/Caravaglio-Capers-Sicily-Pack-2/dp/B008SF2CZK. Most others are fine, including pasteurized honey, sugar (of really any kind), maple syrup, pure jams and jellies. nausea. And dont buy fish from VitalChoice. My father had just died a few weeks before then my mother had a major heart attack, my stress levels were through the roof and being sick on top of it was just an environment for a perfect storm. Please explain. Their tastes are sweet, soft, and nurturing. would like to know whether this is dangerous for the histamine intolerance, cannot find any maple syrup, sweet syrup made by concentrating the sap of certain species of North American maple trees, chiefly the sugar maple and black maple. Maybe tired and foggy. ALLOWED: Salt, pepper, fresh curry leaves, wasabi, fresh herbs and freshly ground spices (except those on the avoid list). The Most GI-Friendly. When treating histamine intolerance, we always try to address the GI disorders first, while supplementing with DAO and NeuroProtek. Everywhere I looked everyone recommended against all peppers. Histamine serves as a neurotransmitter, helps to produce stomach acid, and is an important immune mediator when not going overboard. Heres the cheat sheet, for your own reference. Price Foundation (WAPF) is your source for accurate information on nutrition and health, always aiming to provide the scientific validation of traditional foodways. Hello, HISTAMINE INTOLERANCE https://chrismasterjohnphd.com/blog/2019/03/01/start-here-for-mthfr-and-methylation/#comment-64248, Rachel, I really appreciate your comment, but just wanted to note for others, that your link to Masterjohns page goes to your comment which has nothing to do with glycine. This article is rather cavalier about that. The Histamine Food list Home; About us; . Symptoms of MCAS and the less complex histamine intolerance are not always clearly distinguishable. In the current outbreak of respiratory and neurological illness, the Weston A. Although mast cells also release many other pro-inflammatory substances, histamine gets a particularly bad rap. Even kept in a sealed container, the coconut sugars natural tendency to clump can take over. Would you be kind enough to reconcile the root cause of excessive histamine release you explain at the beginning of the article, Most people have heard of histamine because it is known to cause allergies. Read the guide on any device, online and off. Low Histamine Pizza Recipe (Dough + Sauce), Crispy Baked Cauliflower (Indian Spices, From Frozen or Fresh). Is this a sign of histamine intolerance? Overall, manuka honey is low histamine due to the positive attributes it brings to the table, but most honey is high in histamine due to the sugar content. She has worked in the Hudson Valley Functional Medicine practice since 2011. To prepare the yolks, I separate raw eggs in my hands like you might have been taught to do for baking. People seeking health today often condemn certain food groups -- such as grains, dairy foods, meat, salt, fat, sauces, sweets and nightshade vegetables -- but the WAPF diet is inclusive, not exclusive. Producers plan to tap 7 million more maple trees to meet syrup demand. Sugar does not trigger a histamine response, not does it contain high levels of histamine or DAO-blockers. When beginning the diet, high FODMAP food sources are limited to 2 weeks to 2 months then re-introduced depending on your tolerance. information on this, According to Dr. Janice Joneja (and you guys, in your additives bullet), Benzoates are no good. Maple syrup urine disease (MSUD) is an inherited disorder of branched chain amino acid metabolism presenting with neonatal encephalopathy, episodic metabolic decompensation, and chronic amino acid imbalances. Like most other sweeteners, cane sugar isnt directly high or low in histamine, but the spikes in blood sugar that sweeteners can cause can raise your bodys overall histamine levels, as a response to the inflammation. Use caution with cooked egg whites. ;->. So a liberator that causes the mast cells to degranulate can do a lot of damage (for me). I would live to hear your comments on this exciting research on the drug Votucalis. HISTAMINE LIBERATORS TO AVOID ), overripe or rotten vegetables, all pickled vegetables (or anything that contains vinegar), prepackaged salad or other vegetables. AVOID: All nuts (coconut is a fruit and is allowed), but especially almonds, pecans and walnuts. I react to both and wonder if others do too. Hi, thank you for the detailed and helpful information. a sweet or fruity smell on the breath or skin. Any thoughts as to why that is the case? I give him a DAO vitamin 15 minutes before his meals, and that has helped including with eggs. The SIGHI list scores foods from 0-3, with 0 being low and 3 high histamine. Magazine subscription - your first 5 issues for only 5! I have read in other places to avoid them (I would love to eat them again), because it is a preserved food. Thanks so much for your site and resources. I find this one really confusing. The conditions associated with MCAS are often complex in their own right. The darker syrups are made from sap extracted later in the harvest season. . Maintz L, Novak N. Histamine and histamine intolerance. Black cumin seed (but not regular cumin) has antihistamine properties and is encouraged. Ive been using this Monk Fruit Extract for about a year now, though I found this one to be good as well, and Im keen to try this liquid monk fruit once I run out of my current stash. Your histamine sink can be fuller due to exposure to seasonal allergens, mold, fluctuating hormones, dehydration, stress, etc. Even though this is more than a year old.many people with CFS actually have CIRS from living in a toxic mold-contaminated environment. Cheese. Maple syrup is produced from the sap of maple trees, which is collected from late winter through early spring. We would have saved an enormous amount of money, time and suffering. Short of picking ones own org. FATS AND OILS Slice each potato into thin round-shaped slices, about inches thick. The sap will be filtered again later, after it's boiled. PEA SPROUTS: Although consumption of pea sprouts is optional, it is encouraged when possible. Pro tip, if you like coconut sugar: buy a local brand of coconut sugar, but refill this brands container with the new sugar (which usually comes in a flimsy bag). Bison (PS: Although Ive read some people might boil the whole egg, then remove the white after it is boiled, I wont do that. Unfortunately, most of these sweeteners are by-products of fermentation, and this can increase the inherent levels of histamine in a dish in addition to raising your bodys inflammation level. This diet says plain, artificial sweeteners are okay. Ive been doing keto for multiple chronic digestive issues. The Strictly Low Histamine Diet. FISH/MEAT/POULTRY Sardines are number one. She tried food rotation, ketotifen, quercetin, chromolin, low dose naltrexone, steroids, benzos, beef organs, etc. Fluctuations in blood sugar are bad for your system in general, but high blood sugar levels are also linked to high histamine levels, which is why sugar is classified as an inflammatory food. In recent years, acai bowls have become one of the most hyped-up health foods on the market. Located in Vermont, the Marvin family has been producing and selling local syrup for forty years. And that inflammation causes the mast cells to release even more histamine. I am so confused. The market is rife with competition, dodgy studies and fake reviews. in human nutrition. The honey is prized due to its uniquely active antibiotic properties, which apply whether you use it topically or consume it. Everything helped a little, then most produced other symptoms. This article explains whether maple syrup is healthy or unhealthy. You make it by mixing 1 tsp magnesium hydroxide with a liter of sparkling water (I use whatever is on sale and sometimes I get the flavored ones). Avoid baked goods made with carrageenan, gelatin, tapioca starch, xanthan gum and yeast. Some of these compounds are not present in the maple tree, forming instead when the sap is boiled to form syrup. In the absence of true allergies (immunoglobulin E [IgE] reactions), there are essentially two major scenarios in which this can take place. Any help in clarifying this is appreciated. I also provide careful instructions on how to eat meat and fish. 12. Another side effect of high histamine is anaphylactic shock. Rutab dates have developed to their ripest form, and dried dates are sun-dried for some time before being plucked. Usually about 40 gallons of sap are required to produce one gallon of finished syrup. Some blood sugar-stabilizing foods to keep around include ginger, milk thistle, fenugreek, and bitter melon, all of which youll find in the most reputable herbal remedies for such. Ive contacted the companies themselves, but they couldnt give me a precise answer. I stick with lactobacillus paracasei as the exact stain is almost always given and I came across an article testing 40 different strains of paracasei showing analogous, MC stabilizing results. My son gets hives everytime he catches a virus. In fact, the bodys defense reaction to FOREIGN PROTEINS in the blood is what causes allergies. They are definitely not for me. Therefore, even though the protein content is often comparable, more fruits are liable to be high in histamine or even histamine liberators than are vegetables. Manuka honey is a special type of honey harvested from bees who only gather nectar from the Manuka flower. https://www.umbrelluxdao.com/. Others will have no idea, usually. Theo, and any practitioner who tells you to NOT watch out for high-histamine &/or histamine releasing &/or DAO-supressing foods is doing no-one any favors. I can find no literature to that effect. I have been suffering from what I believe to be MCAS related GI dysmotility, muscle/cutaneous and sub-/joint swelling/ pain/edema/arthralgia, tinnitus, skin hyperactivity, being murdered by warm/hot water, low blood pressure for some time now and have been self treating with supplements and low histamine diet/lifestyle. It has a similar consistency to honey, and the majority of maple syrup comes from Canada. what are the differences between dried dates and fresh dates? ALLOWED: Coffee, fresh raw milk, mineral water, fresh water, chamomile tea, peppermint tea, dandelion tea, ginger tea, rooibos tea, coconut water and coconut milk. You have successfully joined our subscriber list. There are two main steps to maple syrup production: The final product can be used to sweeten many dishes. I am following a low histamine diet and taking medication to stabilize mast cells. In addition I would like to point out that mast cell degranulation and the subsequent histamine release can be triggered by toxins. http://algonot.com/product/neuroprotek/. Are hydroponics safe? Now I can at least make smarter choices as I continue to cut down and eliminate sugar from my diet. A tablespoon (20 g) of pure maple syrup contains 12 grams of sugar, 52 calories and 13 grams of carbs. Histamine blockers also called as antihistamines are medications that block or reduce histamine to stop the symptoms of allergy. As part of the immune system, mast cells and histamine trigger your body's inflammatory response when it sense irritants like pollen or dander. Sprinkle the potatoes with salt and black pepper (freshly ground). I keep seeing quercetin as a mast cell stabilizer but I dont metabolize sulfa well (I get a head to toe rash) so Ive also read to avoid quercetin. Yasmina used to say something like elemination doesnt heal nutrition does. Pay attention to how you react to foods, ingredients in it and how its made. She writes, " unstable blood sugar can increase histamine levels, and histamine levels can progress the development of diabetes or insulin resistance.". Though note that the difference between those & these isnt necessarily about the GI of any of them, because you shouldnt be eating many sweets anyway. I can eat any type of food including high histamine foods (I have to eat those in moderation) but I dont tolerate additives and food thats been sulfited. This Date Sugar is the same one I have in my cabinet, and I mostly rely on it for sprinkling on top of fresh fruit with coconut cream, as Ive recently found that it blends in & sort of melts much better than coconut sugar. Related conditions may include allergies, autism, autoimmune disorders, cancer, diabetes, Ehler-Danlos syndrome, postural orthostatic tachycardia syndrome (POTS), fibromyalgia, Lyme disease, mastocytosis, migraines and obesity. To determine whether an IgE-mediated mechanism plays a pathogenetic role in this disorder, we measured histamine release after in vitro exposure to epigallocatechin gallate. Unfortunately, this can really wreak havoc in the body. Ive listed them in order of Glycemic Index ranking, and added any other common names in parentheses. 1. Antihistamines help with symptoms which are mostly postnasal drip tickly cough and mild wheezing as well as insomnia. Most histamine websites list raw milk as a high histamine food. are regarded as low histamine when they are a dried fruit? SWEETENERS Excess fructose is not the only potential problem; syrups can potentially develop some oligosaccharides during the manufacturing process. It's true that maple syrup is high in sugar in the form of sucrose, but it also contains various other components, such as oligosaccharides, polysaccharides, organic acids, amino acids, vitamins and minerals. Please help I tired everything. I am not a nutritionist but use rice bran oil and coconut oil which tolerate high heat, also ceramic pan which encourages lower heat, supplement quercitin and 500 mg pantothenic acid, recommended by Adele Davies fifty years ago, terrible hay fever without it1. Soy sauce, tamari, coconut aminos, liquid aminos. For MCAS, the situation is much more complex. On the other hand, many are "evened out" by potent levels of mast cell-stabilizing substances, making them natural antihistamines themselves. Heat 2 tablespoons olive oil in a large skillet on medium heat. Making it nearly impossible to know which one youre ingesting. 2005-2023 Healthline Media a Red Ventures Company. Nuts Consumed in excess, sugar may be a leading cause of some of the worlds biggest health problems, including obesity, type 2 diabetes and heart disease (3, 4, 5). agave syrup: High fructose content-----stevia (stevia leaves, liquid, powder)----- . Thanks. In a large bowl combine squash, olive oil, maple syrup, molasses, vanilla extract, eggs. I occasionally see posts that indicate that Green Tea is high in histamine because it is fermented (like black tea, etc.). But, I would like to know if I am doing further damage by eating cocoa at all. It seems a lot of GPs are not all that conversant with either problem. Digestion alone causes histamine release (Yasmina said that was pivitol in changing her outlook) so its ultimately not about the food its about inflammation and however you lower that is an individual thing. Also remember that when using safe sweeteners like those above, your main concern is really whether you need solid or liquid sweetness, and how much you can substitute the bulk of sugar for a fine powder like monk fruit or stevia. Everything else is okay. Parmesan contains 1,680 milligrams of glutamate per 100 grams and Roquefort contains 1,280 milligrams . Calories and Nutrition. If Im baking it, I dont worry about the membrane thats over the yolk. Im also a forager and one who gravitates towards medicinal foods so Im wondering about wild greens and histamine as well as oxalates. I usually have an attack when histamine count rises. HERBS AND SPICES In the article I noticed that there are several items that are not protein dense (alcohol, strawberries, tomatoes, cacao, citrus), at least as far as I understand the 4 macronutrient classification (proteins, fats, carbs, alcohol). I had only ever heard that term used as an adjective to describe something overly-sweet, but after a bit of googling I found some explanations of it as an artificial sweetener. Indeed-- sugar is sugar, though some come with some extra nasties to watch out for. Whether or not it is desirable to eat sugar at all is another question entirely. Hello, Gibbs list offers the strictest interpretation of what may constitute a problematic food for histamine; I have loosened it up a little to allow some sprouted beans. How about white tea? There are at least two possible reasons why someone would absorb excess histamine from the gut. 5. Author links open overlay panelToshihiroShiraiMDAtsuhikoSatoMDKingoChidaMDHiroshiHayakawaMDJinichiroAkiyamaMDMasatoshiIwataMDMasamiTaniguchiMDKhaledReshadMDYukihikoHaraPhD Methylation refers to the process of any molecule being transformed by the addition of a methyl group (CH3)three hydrogen atoms bonded to a carbon atom. You will find the highest levels of glutamate in parmesan and Roquefort cheeses. Dark amber has a stronger maple flavor and is also used as table syrup, depending on individual preferences. The detailed low-histamine diet (next page) is as strict as they come. I'm honestly not sure why dates are sometimes regarded as low histamine and other times not. One company bought up the rights and charges monopolistic prices. Donate to the food pantry and get it out of the . What Is Histamine Intolerance? Cause gastrointestinal disturbances due to rich histamine content with body's inability to break down histamine due to pancreatic insufficiency. Learn more about which foods are low and high histamine in the Happy Without Histamine - Low Histamine Foods Guide. Sucrose (white sugar, table sugar, cane syrup, maple syrup) Maltose (brown rice syrup) Stevia. Step #1: Get rid of all of the "bad stuff". There is research showing that DAO supplementation reduces histamine levels,7 and quercetin and luteolin reduce the release of histamine and tryptase from mast cells.8 More research is forthcoming in this area, including the results of a just-completed clinical trial.9. The Weston A. Make sure all of the oats are submerged in the milk. Make sure the sparkling water is cold to reduce the foaming action of the magnesium hydroxide. The result is vibrant health for every age of life, including the next generation. A variety of factors will lead you to burying the white sugar even deeper in your pantry, but it might have surprised you to see things like xylitol and agave on the no-no list. If you also choose to use honey on a low histamine diet, make sure its raw or minimally processed. Spices Lowest: cinnamon, turmeric Low/Med: ginger, nutmeg, poppy seeds, vanilla extract Avoid: soy sauce, balsamic & wine vinegars Tea: Lowest: chamomile, peppermint tea, holy basil, verbena, rooibos Avoid: black tea Other Beverages: Maple syrup offers some impressive health benefits of its own, particularly because of its high amounts of manganese and riboflavin. I see that green and black teas are on the no fly list. This is a detailed review of the Truvia sweetener, looking at its health effects and nutritional properties. Study to investigate the effect of an oral diamine oxidase substitution (DAOsin) in histamine intolerant patients on the low endogenous diamine oxidase serum activity. You could also reach in and remove large pieces of debris with a slotted spoon. Maple syrup is a less bad version of sugar, much like coconut sugar. I have had great success taking aged cascara bark in the morning and Benfotiamine + Alpha-Lipoic Acid. That's where Butternut Mountain Farm's maple syrup comes in. Quercetin, DAO, vit C and my own personal list of foods to avoid have lessened my symptoms at least 90%. Theyre all nutrient-dense, natural alternatives to processed sugars whether youre on a low histamine diet or not. At that time, just adding glycine calmed my brain without it I would get agitated, angry, easily annoyed. After reading about histamine and oestrogen here, which again explains a lot of what has happened to me over the years, I was interested to know how histamine reacts with pytooestrogen, which I have also had problems with. Required fields are marked *. Yes, maple syrup is low histamine in small amounts. Components. In fact, the bodys defense reaction to foreign proteins in the blood is what causes allergies. Truvia is a popular sugar substitute. Of those 55.6 grams, 50.2 are sugars. "We don't need much of it, but it's essential for our body to operate efficiently. Histamine intolerance. Hello, thank you for this informative post. THANK YOU. Individuals who are not sure about the extent to which histamine is affecting them might first want to try the less strict list described in the previous section, keeping in mind that many people do better with the stricter diet. Price Foundation extends heartfelt sympathy to all patients, health care workers and those adversely affected economically by public health measures. Excess estrogen levels also can increase circulating histamine because estrogen suppresses DAO activity and stimulates mast cells. Int J Immunopathol Pharmacol 2016;29(1):105-111. https://doi.org/10.1016/S1081-1206(10)63087-6Get rights and content After centrifugation, histamine was measured in the cell-free supernatants by radioimmunoassay. Price and the power of using food as medicine, which sparked a passion for a new career in health and nutrition and for improving her and her family's health. Maple syrup: Anything that increases your blood sugar increases histamine levels.----- Pea sprouts can be used liberally as they are high in the DAO enzyme, which helps break down histamine. Methods The conditions associated with MCAS are often complex in their own right. Dont get hung up on lists and benzoates, sulfates, oxalates, histamine etc in foods. Youll note that honey is not mentioned on either the list above or below. Break the shell, then let the egg drop out of the shell into your hand. AVOID: Alcohol-based flavors, anise, artificial flavors, brewers yeast, cayenne pepper, chili, chocolate, cinnamon, cloves, cocoa, curry, mace, mustard seed, nutmeg, smoke flavor, soy sauce and all soy products, tamari, tamarind (fermented), thyme, vinegar of all kinds and any food containing vinegar. Some say you can eat sugar in moderation, while others recommend avoiding it completely. It is a definite no on some lists and a yes on other lists. It is listed as an anti-histamine food/beverage on some websites. When determining high-histamine fruit, you must consider whether a particular fruit contains biogenic amines other than histamine. Molecular Immunopharmacology & Drug Discovery Laboratory. Anything aged more than 24 hours will be high histamine. There are several different grades of maple syrup characterized by color, though classification can vary between countries. Error in your article names Dr. Most actual alt sweeteners are highly concentrated but companies also like a product that measures like sugar. We like to start with the basics and move to considering complex conditions like histamine overload or mold toxicity only after we have optimized nutrition and GI function. Whats a good histamine lowering probiotic. Thanks in advance! Thank you so much for the comprehensive lists, and explainations.. Ive suspected this intolerance and histamine overload for many years now and after much digging re: symptoms.. had reduced a few of the restricted foods for well over a year, and even more foods recently. I tend to stay away from those as a general rule, due to a strong family history of cancer and the fact that I find monk fruit and other fruit-derived sugars to be perfectly fine, but I haven't looked into them in regards to HIT. Please look at Akari Theraputics Akaritx.com. I wouldnt go by this list. What ways do you recommend healing my gut? VEGETABLES: Add the following to dishes as much as possible: artichokes, basil, broccoli, celery, chives, cilantro, dill, garlic, onions (either cooked onions or spring onions in small amounts), oregano, parsley, rosemary, snap peas, watercress, and ancho, serrano and chili peppers. But more people seem to report a chemical aftertaste, so consider yourself warned. Cutting sugar and grains has made THE MOST difference of any health-related change I've made in my life. I have recently found out I have a histamine intolerance and possibly the mast cell condition. Not all of us are affected by all liberators, but egg whites have been a biggy for me for decades, even before I knew I had this. Add ground oats/chia seed and GF all purpose flour blend and baking powder to wet ingredients. However the actual sweetener, sucralose, is ok for keto. There are many syrups that kind of look the same called "pancake syrup" and these are loaded with other sugars, often high FODMAP high fructose corn syrup (HFCS), so not only are these not nearly as delectable and maple-y, but they would also be high in FODMAPS. Over time, it will become easier to identify foods that are particularly problematic. Would L. Rhamnosus be a good probiotic? Some allowed herbs and spices include: allspice, basil, bay leaf, caraway, cardamom, chives, coriander (cilantro), fenugreek, garlic, ginger root, marjoram, mint, myrtle leaf, oregano, parsley, peppermint, pimento leaf, rosemary, sage, savory, sumac, tarragon and turmeric. Hello & welcome! Symptoms can include rashes, hives, itching, flushing, fainting, headache, abdominal pain, nausea, vomiting, gastroesophageal reflux disease (GERD), fatigue, chronic pain, trouble breathing and many more. (When buying fish from a local market, make sure that the vendor is trustworthy and the fish is of the best quality.) Is there a type of quark that would be low histamine? NUTS Rice is a huge no-no for me as is potato of any kind and all types of flour. For meat and poultry, grassfed is best. I have more questions and possible solutions: Hi! Beans do contain some of the DAO enzyme but they also contain some histamine. When sprouted the DAO content goes up. Maple syrup is about 2/3 sucrose, or table sugar 1/3 cup (80 ml) supplies around 60 grams of sugar. Worst Sweeteners For Histamine Intolerance, which can lead to an even more unhappy gut. I have had problems with yogurts specifically cultured with L. casei. Monk Fruit vs. Stevia: Which Sweetener Should You Use? The information below is adapted from the list provided in the book, Is Your Food Making You Sick? One study estimated that replacing all the refined sugar in the average diet with alternative sweeteners like maple syrup would increase your total antioxidant intake as much as eating a single serving of nuts or berries (9). ALLOWED: Apples, coconut, fig, goldenberries, longans, loquat, lychees, mango, melon, passionfruit, persimmon, pomegranate, quince, rhubarb and starfruit. I just wanted to note that as far as my research has gone, L. casei strains should be avoided as they have the potential to increase histamine production in foods (and therefore food fermented in the large intestine), and of course this can be strain dependent. Additives (benzoate, sulfites, nitrites, glutamate and food dyes). So while I wouldn't recommend any such sweeteners during the first month or so of your low histamine/elimination diet, I reintroduced them around month 3 and had no issues, though every story is different. I am having some serious itchy hive reactions, which scratching has made worse, it just isnt healing. 6. Nice! I have high levels of candida (had the organic acids test done through Great Plains Laboratory) and moderate levels of yeast in my gut. Contains Some Vitamins and Minerals But Is High in Sugar. Histamine release was expressed as a percentage of total histamine. GRAINS/BAKING I have mast cell activation likely triggered by chronic Lyme and mold exposures. The easiest way to use them is to juice or blend them and drink with meals. We have to be on our toes :)). Histamine is a chemical that is released by a type of white blood cell called mast cell in response to allergies or injuries.